Products
Protub®-3
Pharmacotherapeutic group
Antituberculosis drugInternational name
Isoniazid + Pyrazinamide + RifampicinDosage form
TabletsProduct information
Download Protub®-3.pdf (RU)
Go to the State Register of Medicinal Products site ➞
Antituberculosis fixed-dose combination. It has a bactericidal effect against Mycobacterium tuberculosis at various stages of its development. Isoniazid inhibits synthesis of mycolic acids in M. tuberculosis cell wall, has specific activity against Mycobacterium tuberculosis, rapid growing extra- and intracellular bacteria, including strains resistant to other drugs. Rifampicin is a semisynthetic antibiotic that inhibits DNA-dependent polymerase; it is active against rapid-growing, intermittently growing extra- and intracellular bacteria. Pyrazinamide is active against intracellular mycobacteria and penetrates well into tuberculous lesions. It shows no decrease in activity at an acid pH of caseous lesions. Depending on the dose, pyrazinamide exerts a bactericidal or bacteriostatic effect.