Products
Rifampicin
Pharmacotherapeutic group
Rifamycin antibioticInternational name
RifampicinDosage form
Coated granulesAntituberculosis drug. It is a broad spectrum semisynthetic antibiotic. At low concentrations, rifampicin has a bactericidal effect against Mycobacterium tuberculosis, Brucella spp., Chlamydia trachomatis, Legionella pneumophila, Rickettsia typhi, Mycobacterium leprae, and against some Gram-negative microorganisms when used at high concentrations. It is effective against both extra- and intracellular microorganisms and inhibits their DNA-dependent RNA-polymerase. When used as monotherapy, rifampicin resistant bacteria are selected relatively quickly. No cross-resistance with other antibiotics develops.