Products
Modena®
Pharmacotherapeutic group
Immunosuppressant, multiple sclerosis drugInternational name
FingolimodDosage form
CapsulesMultiple sclerosis drug. Fingolimod is a is a sphingosine-1-phosphate (S1P) receptor modulator. It is metabolized by sphingosine kinase into fingolimod-phosphate, its active metabolite. At low nanomolar concentrations, fingolimod-phosphate binds to lymphocyte S1Р-receptors of type 1, 2, ,3, and 4 and quickly crosses the blood–brain barrier (BBB) binding to neuron S1Р-receptors of type 1, 2, ,3, and 4. By binding S1P-receptors of lymphocytes, fingolimod-phosphate blocks the capacity of lymphocytes to egress from lymph nodes, resulting in re-distribution of lymphocytes in the body. At the same time, there is no decrease in total lymphocyte counts in the body.
Re-distribution of lymphocytes leads to a decrease in lymphocytic infiltration into the central nervous system, severity of inflammation, and nervous tissue damage.