Products
Celixel
Pharmacotherapeutic group
Antineoplastic agents; plant alkaloids and other natural substances; taxanesInternational name
PaclitaxelDosage form
Concentrate for solution for infusionAntineoplastic drug. It is a mitosis inhibitor. Paclitaxel specifically binds to the β-tubulin subunit in microtubules preventing depolymerization of this key protein which results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, paclitaxel induces abnormal arrays of microtubules throughout the cell cycle and formation of multiple centrioles during mitosis.