Russian Pharmaceutical Industry Leader


Linezolid solution for infusion
Pharmacotherapeutic group
Oxazolidinone antibiotic
International name
Dosage form
Solution for infusion
Description Manufacturer Pharmacies Leave a feedback
Linezolid, a synthetic antibacterial drug, belongs to a new class of oxazolidinones, antimicrobial agents showing an in vitro activity against aerobic Gram-positive bacteria, some Gram-negative bacteria, and anaerobic microorganisms. Linezolid selectively inhibits bacterial protein synthesis. It binds to bacterial ribosomes thereby preventing the 70S initiation complex formation which is a key element of the translation initiation in protein synthesis. It shows both in vitro and in vivo activity: Gram-positive aerobes: Enlerococcus faecium (including vancomycin resistant strains), Staphylococcus aureus (including methicillin-resistant strains), Streptococcus agalactiae, Streptococcus pneumoniae (including multiresistant strains), Streptococcus pyogenes. It has an in vitro activity against: Gram-positive aerobes: Enterococcus faecalis (including vancomycin resistant strains), Enlerococcus faecium (vancomycin-susceptible strains), Staphylococcus epidermidis (including methicillin-resistant strains), Staphylococcus haemolyticus. Viridans streptococci. Gram-negative aerobes: Pasteurella multocida Linezolid resistant microorganisms: Haemophilus influenza, Moraxella catarrhalis, Neisseria spp., Enterobacteriaceae spp., Pseudomonas spp.. Resistance Linezolid has a mechanism of action which is different from that of other types of antibiotics (such as aminoglycosides, beta-lactams, folic acid antagonists, glycopeptides, lincosamides, fluoroquinolones, rifamycins, streptogramins, tetracyclines, and chloramphenicol) that is why there is no cross resistance between linezolid and these drugs. Linezolid is active against microorganisms that are both susceptible and resistant to the above antimicrobial agents. Linezolid resistance emerges slowly by a multistep mutation of 23S ribosomal RNA at a frequency of less than 1х10-9 - 1х10-11.
* — Required field
Данный сайт содержит информацию о лекарственных препаратах, отпускаемых по рецепту.

В соответствии со статьей 67 Федерального закона от 12.04.2010 № 61-ФЗ «Об обращении лекарственных средств» материалы данного сайта предназначены (и могут быть доступны) исключительно для медицинских и фармацевтических работников. АО «Фармасинтез» не несет ответственность за возможные негативные последствия, возникшие в результате использования информации данного сайта без предварительной консультации со специалистом лицами, не являющимися медицинскими и фармацевтическими работниками.
Choose who you are: