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Orgasporin®
Pharmacotherapeutic group
Immunosuppressant
International name
Cyclosporine
Dosage form
Capsules
Description Manufacturer Pharmacies Leave a feedback
Immunosuppressant, cyclic polypeptide of 11 amino acids. Cyclosporine exerts selective actions on T cells: it prevents their activation and, at the cellular level, inhibits antigen-induced secretion of lymphokines, including interleukin-2 (T-cell growth factor). It has a specific and reversible effect on lymphocytes. Unlike cytostatic agents, it does not depress haemopoiesis and has no effect on the function of phagocytic cells. Cyclosporine prolongs survival of allogeneic transplants of skin, heart, kidney, pancreas, bone marrow, small intestine or lung. It also inhibits the development of cell-mediated reactions, including allograft immunity, delayed cutaneous hypersensitivity, experimental allergic encephalomyelitis, Freund's adjuvant arthritis, graft-versus host disease (GVHD), and also T-cell dependent antibody production. Cyclosporine has been shown to be effective for the prevention and treatment of graft rejection and GVHD after solid organ and bone marrow transplantations and for the treatment of a variety of conditions that are known, or may be considered to be of autoimmune origin.
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