Amikacin

A broad-spectrum semisynthetic aminoglycoside antibiotic with bactericidal activity. It actively penetrates the bacterial cell membrane and binds irreversibly to the 30S subunit of bacterial ribosomes, thereby inhibiting protein synthesis in the pathogen.

It is highly active against aerobic Gram-negative bacteria: Pseudomonas aeruginosa, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp., Enterobacter spp., Serratia spp., Providencia stuartii.

It is also active against certain Gram-positive bacteria: Staphylococcus spp. (including strains resistant to penicillin, methicillin and certain cephalosporins), and certain strains of Streptococcus spp.

It is inactive against anaerobic bacteria.