Docvir

Tenofovir disoproxil fumarate and emtricitabine fixed-dose antiviral combination. It possesses specific activity against human immunodeficiency virus (HIV-1 and -2) and hepatitis B virus. Tenofovir, a nucleoside monophosphate (nucleotide) analogue of adenosine monophosphate is a nucleotide reverse transcriptase inhibitor. Emtricitabine is a nucleoside analogue of cytidine. Synergistic antiviral activity was observed with the fixed-dose combination of emtricitabine and tenofovir in vitro. Additive to synergistic effects were observed in combination studies with protease inhibitors and with nucleoside and non-nucleoside analogue inhibitors of HIV-1 reverse transcriptase.