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Pharmacotherapeutic group
Antimicrobial drug, fluoroquinolone
International name
Dosage form
Description Manufacturer Pharmacies Leave a feedback
Antimicrobial agent, fluoroquinolone derivative. It inhibits bacterial DNA gyrase that decondensates chromosomal DNA (which is essential for genetic code reading). Its low toxicity to host cells is due to the fact that gyrases are absent from higher eukaryotes. Sparfloxacin is a broad-spectrum bactericidal antimicrobial agent (active primarily against Gram-negative microorganisms, similar to aminoglycosides). It is active against Gram-positive microorganisms only when they are replicating; however, it is active against Gram-negative microorganisms in the resting stage also since, in addition to inhibiting DNA gyrase, it lyses the bacterial cell wall. Sparfloxacin prevents genetic material transcription required for normal metabolism which results in a rapid decrease in the ability of bacteria to divide. Its use does not lead to an emergence of resistance to other types of antibiotics that do not belong to the gyrase inhibitor group which makes it highly effective against bacteria resistant, for instance, to aminoglycosides, penicillins, cephalosporins, tetracyclines, and many other antibiotics.
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