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Pharmacotherapeutic group
antibiotic-carbapenem+dehydropeptidase inhibitor
International name
Dosage form
powder for preparation of solution for infusion
Description Manufacturer Pharmacies Leave a feedback
Aquapenem consists of two components: imipenem, the first representative of a new class of beta-lactam antibiotics - thienamycins, and cilastatin - a specific enzyme-inhibitor that inhibits imipenem metabolism in the kidneys and significantly increases the concentration of unchanged imipenem in the urinary tract. Cilastatin has no intrinsic antibacterial activity and does not inhibit bacterial beta-lactamase.
Aquapenem inhibits the synthesis of the cell wall of bacteria and has a bactericidal effect against a wide range of Gram-positive and Gram-negative microorganisms, aerobic and anaerobic.
The drug's resistance to destruction by bacterial beta-lactamase makes it effective against many microorganisms, such as Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, which are resistant to most beta-lactam antibiotics, as well as anaerobes (Bacteroides fragilis). The antibacterial spectrum includes virtually all clinically significant pathogens.
Active against the following microorganisms in vitro, as well as in vivo: Gram-negative aerobes: Acinetobacter spp., Citrobacter spp., Enterobacter spp, Escherichia coli, Gardnerella vaginalis, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella spp., Morganella morganii, Proteus vulgaris, Providencia rettgeri, Pseudomonas aeruginosa, Serratia spp. including Serratia marcescens;
Gram-positive aerobes: Enterococcus faecalis, Staphylococcus aureus (including penicillinase-producing strains), Staphylococcus epidermidis (including penicillinase-producing strains), Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes;
Gram-negative anaerobes: Bacteroides spp. including Bacteroides fragilis, Fusobacterium spp;
Gram-positive anaerobes: Bifidobacterium spp., Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp., Propionibacterium spp.; Imipenem has bactericidal effect in vitro on the following microorganisms: Gram-positive aerobes: Bacillus spp, Listeria monocytogenes, Nocardia spp., Staphylococcus saprophyticus, Streptococcus groups C, G and viridans; Gram-negative aerobes: Aeromonas hydrophila, Alcaligenes spp., Capnocytophaga spp., Haemophilus ducreyi, Neisseria gonorrhoeae, including strains forming penicillinase, Pasteurella spp., Providencia stuartii;
Gram-negative anaerobes: Prevotella bivia, Prevotella disiens, Prevotella melaninogenica, Veillonella spp;
Insensitive: Enterococcus faecium, methicillin-resistant Staphylococcus spp., Xanthomonas maltophilia, Pseudomonas cepacia.
In vitro it acts synergistically with aminoglycosides against some strains of Pseudomonas aeruginosa.
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